Does the epigenetic expression of obesity, insulin resistance and their metabolic sequelae contribute to brain senescence?

Cognitive senescence and brain shrinkage have been reported in Alzheimer’s disease is often associated with obesity but the pathophysiologic factors which bring about neural declines remain unclear. A retrospective examination of Insulin resistance lean obese rats indicated that final body weights phenotype were more than double those their littermates throughout adulthood, carcass fat content at 10.5 months age 15-fold greater similarly fed littermates. In addition, life span was decreased by approximately 30% both male female compared to glycemic parameters developed significant insulin resistance, while lipid, protein DNA significantly reduced one third or ~10 age, when they had approached peak weights. These observations suggest onset progression its metabolic sequelae contributes shrinkage, content, key development cognitive aging this strain rat.